Recent Publications and News

 

-Prof. Pintauer receives NSF Career Award!

-Pintauer Research Group reveals magic ingredient that turns radical reactions “green”. Read Chemical Science instant insight article published by the Royal Society of Chemistry.

Green ATRA Reactions

-Ricardo, C.; Pintauer, T. “Copper Catalyzed Atom Transfer Radical Cascade Reactions in the Presence of Free-Radical Diazo Initiators as Reducing Agents”, Chem. Commun. 2009, 3029.

-Matt and Ashley’s video has been selected as one of the winning entries for Nationwide Undergraduate Chemistry Video Competition.  See the video on you tube

Tomislav Pintauer, Ph.D.

Assistant Professor

Duquesne University, Department of Chemistry and Biochemistry

600 Forbes Avenue, 308 Mellon Hall, Pittsburgh, PA 15282

Tel: 412-396-1626; Fax: 412-396-5683

Email: pintauert@duq.edu

The addition of halogenated compounds to alkenes or alkynes through a radical process is one of the fundamental reactions in organic chemistry.  It was first reported in the early 1940s in which halogenated methanes were directly added to olefinic bonds in the presence of radical initiators or light.  Today, this reaction is known as the Kharasch addition or atom transfer radical addition (ATRA), and it is generally catalyzed by transition metal complexes.The principal reason for small participation of metal mediated atom transfer radical addition (ATRA) and cyclization (ATRC) reactions in complex molecule and natural


product  synthesis is the large amount of catalyst needed to achieve high selectivity towards the desired target compound. This obstacle causes serious problems in product separation and catalyst regeneration, making the process environmentally unfriendly and expensive.  The main objective of our research is to overcome the drawbacks of metal catalyzed ATRA and ATRC reactions by utilizing reducing agents that enable significant reduction in the amount of metal catalyst.  Our research bridges inorganic, organic and organometallic chemistry and aims to transform metal mediated ATRA and ATRC reactions into an environmentally friendly and inexpensive process.  Research projects are discussed in detail on the following pages.


Atom transfer radical addition and cyclization reactions mediated by transition metal complexes